Preclinical Assessment of Naloxone Adequacy to Reverse Polysubstance Use-Induced Respiratory Depression — In Vivo Validation

Where this opportunity stands

Every notice posted under solicitation 75F40126Q00382 in this department, oldest first.

Next steps for this stage

Standard steps for the notice type; not advice about this buyer.

• Answer the notice: this is when the requirement can still be shaped.
• Contact the contracting officer named on the notice.
• Check who won similar work; they are the likely bidders.

Who won similar work

4 award notices on SAM.gov in the last 24 months. Matched by: Same agency (FDA), same NAICS 541714.

Single-winner award sizes (4): middle half $16.5M to $67.7M, median $33.4M; range $15.7M to $120.8M.

Value counts single-winner awards. "Shared" awards are multiple-award contracts that list every winner with the same total ceiling; that ceiling is not one company's win, so it is not added in. Revenue next to a ticker is the company's last annual revenue from its 10-K.

• Oct 8, 2026Please_See_Spreadsheet Silver Spring MD 20993 USA$120.8MFY26 FDA Broad Agency Announcement (BAA) for Advanced Research and Development of Regulatory ScienceNo listed company matched (Materiality N/A)
• Jan 13, 2026Please_see_Spreadsheet Silver Spring MD 20993 USA$16.7MFY25 FDA Broad Agency Announcement (BAA) for Advanced Research and Development of Regulatory ScienceNo listed company matched (Materiality N/A)
• Jan 8, 2026Please_see_Spreadsheet Silver Spring MD 20993 USA$15.7MFY25 FDA Broad Agency Announcement (BAA) for Advanced Research and Development of Regulatory ScienceNo listed company matched (Materiality N/A)
• Sep 16, 2025TRANQUIL CLINICAL AND RESEARCH CONSULTING SERVICES LLC$50.0MFood and Drug Administration (FDA) Office of Clinical Pharmacology (OCP) � Multi-phase/Multi- site Clinical Studies and Laboratory Support Indefinite Delivery-Indefinite Quantity (IDIQ) Type ContractNo listed company matched (Materiality N/A)

Competitive landscape

For the 2 most frequent past winners above. Lobbying is matched by the company's exact name or exact ticker; agencies are as named on the filings.

Policy around it

Bills the past winners named while lobbying this agency's issues, rules from the department, and executive orders that name the agency, last 12 months.

Market

For past winners matched exactly to a listed company. Insider trades are open-market buys and sells (Form 4) in the last 90 days, shown as facts; our own study found insiders do not reliably buy ahead of awards. A sale marked 10b5-1 was made under a trading plan set up in advance.