Protein ENGineering (PENG)
DARPA · DEF ADVANCED RESEARCH PROJECTS AGCY
Capture briefs (a one-page, shareable copy of this page) are part of Pro. The CSV here holds the notice, its timeline and past awards.
Where this opportunity stands
Every notice posted under solicitation DARPA-PS-26-129 in this department, oldest first.
- Aug 7, 2026 · this noticeSolicitation
- Aug 21, 2026SolicitationOpen
Next steps for this stage
Standard steps for the notice type; not advice about this buyer.
- Decide bid or no bid before the response deadline.
- Look at the past winners for likely competitors and teaming partners.
- Follow the opportunity to hear about amendments and the award.
What the notice says
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, tar… (show all)
get-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.
Who won similar work
5 award notices on SAM.gov in the last 24 months. Matched by: Same office (DEF ADVANCED RESEARCH PROJECTS AGCY), same product/service code (PSC) AC12 and NAICS 541714.
Single-winner award sizes (5): middle half $999K to $1.4M, median $1.2M; range $693K to $11.2M.
| Winner | Awards | Value | Last |
|---|---|---|---|
| NATIONAL COLLEGIATE INVENTORS & INNOVATORS ALLIANCE, INC. | 2 | $2.4M | Jun 23, 2026 |
| UNIVERSITY OF MARYLAND, COLLEGE PARK | 1 | $11.2M | Nov 26, 2024 |
| ENGINEERING BIOLOGY RESEARCH CONSORTIUM Emeryville CA 94608 USA | 1 | $1.2M | Jun 23, 2026 |
| The Council on Strategic Risks Washington DC 20036 USA | 1 | $693K | Oct 21, 2025 |
Value counts single-winner awards. "Shared" awards are multiple-award contracts that list every winner with the same total ceiling; that ceiling is not one company's win, so it is not added in. Revenue next to a ticker is the company's last annual revenue from its 10-K.
- Jun 23, 2026ENGINEERING BIOLOGY RESEARCH CONSORTIUM Emeryville CA 94608 USA$1.2MBiosecurity Working Group Generative Optogenetics
- Jun 23, 2026NATIONAL COLLEGIATE INVENTORS & INNOVATORS ALLIANCE, INC.$1.4MIndependent Commercialization Generative Optogenetics
- Oct 21, 2025The Council on Strategic Risks Washington DC 20036 USA$693KPolicy Working Group for Switch Biomanufacturing
- Feb 3, 2025NATIONAL COLLEGIATE INVENTORS & INNOVATORS ALLIANCE, INC.$999KHR001125C0049 Biological Technologies
- Nov 26, 2024UNIVERSITY OF MARYLAND, COLLEGE PARK$11.2MHR001125C0004 BioLogical Undersea Energy (BLUE)
Competitive landscape
For the 4 most frequent past winners above. Lobbying is matched by the company's exact name or exact ticker; agencies are as named on the filings.
- 0 of these past winners lobbied Defense Advanced Research Projects Agency (DARPA) since 2024 (0 filings)
- 0 of their lobbyists list a past Defense Advanced Research Projects Agency (DARPA) job
- No corporate PAC money from them to the overseeing committees since 2024
- 0 foreign-agent (FARA) registrations
Policy around it
Bills the past winners named while lobbying this agency's issues, rules from the department, and executive orders that name the agency, last 12 months.
- 0 bills named on the past winners' lobbying filings
- 32 rules from the department in the last 12 months
- 0 executive orders naming the agency in the last 12 months
Market
For past winners matched exactly to a listed company. Insider trades are open-market buys and sells (Form 4) in the last 90 days, shown as facts; our own study found insiders do not reliably buy ahead of awards. A sale marked 10b5-1 was made under a trading plan set up in advance.
- 0 of the past winners are listed companies
- 0 insider buys and 0 insider sells at them in the last 90 days
Sources: SAM.gov notices and award notices; Senate LDA lobbying filings; FEC filings; FARA; Federal Register; congress.gov; SEC Form 4. Every row above links to its record.
Companies are matched to tickers by exact name only. A company we could not match shows no market rows; that is a miss, not a finding.