Bruker Biospin Nuclear Magnetic Resonance (NMR) and Q-Band Electron Paramagnetic Resonance Equipment

Resonance Equipment Upgrades to Expand Research Capabilities and Replace End-of-Life Instrumentation or Equal. SEE ATTACHMENT for Bruker Biospin NMR Product List This acquisition is being conducted as an open market purchase. The Government intends to award a Firm-Fixed-Price Purchase Order resulting from this solicitation. 2. Description of Requirement 2.1 Background The National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Laboratory of Chemical Physics (LCP), conducts advanced research in biomolecular structure, conformational dynamics, and molecular mechanisms using nuclear magnetic resonance (NMR) spectroscopy and electron paramagnetic resonance (EPR) spectroscopy. The advanced NMR and EPR instrumentation in the LCP support mission-critical biomedical research. The federally conducted research programs focus on: Structural and dynamic characterization of proteins and nucleic acid Mechanisms of phosphorylation and regulation in intrinsically disordered proteins Transient conformational states associated with ligand and substrate binding Sparsely populated excited states of proteins associated with macromolecular recognition, allostery, assembly and fibril formation Long-range distance measurements in biomolecules using pulsed Q-band EPR techniques This research supports NIH�s mission to advance fundamental knowledge of biological systems and to improve understanding of disease mechanisms relevant to diabetes, metabolic disorders and related conditions, and neurodegenerative conditions associated with protein fibril formation and aggregation leading to a variety of amyloidosis. High-field 600-MHz NMR spectrometers equipped with cryogenic probe technology and Q-band pulsed EPR spectrometers capable of Double Electron-Electron Resonance (DEER) measurements are essential infrastructure for this research. These complementary methods provide distance measurements and structural and dynamic information that is not obtainable by other biophysical techniques. NMR provides atomic resolution information that allows almost every atom in a protein to be probed. While one of the main sources of structural information provided by NMR relates to interproton distances separated by less than 5-10 �, pulsed Q-band EPR spectroscopy, particularly Double Electron�Electron Resonance (DEER) enables distance measurements between pairs of paramagnetic centers ranging from 20-160 �. When combined with rapid mixing/freeze-quenching methods, DEER measurements can provide critical insight into kinetics and mechanisms of conformational transitions. 2.2 Objective To obtain NMR and Q-Band Electron Paramagnetic Resonance Equipment Upgrades to Expand Research Capabilities and Replace End-of-Life Instrumentation 3. Product Specifications/Features/Salient Characteristics Required Minimum Specifications See Attachment. 3.1 Services Requirements The vendor shall provide: 1. Delivery to NIH Main campus in Bethesda, MD. 2. Installation and operational startup. 3. Manufacturer warranty coverage; and 4. Manufacturer-supported service associated with the delivered system. 4. Delivery, installation, startup shall be performed at: National Institutes of Health Bldg. 5, Room B1-3001 Bethesda, MD 20892 5. Basic For Award The Government intends to award to the quoter whose quotation represents the best value to the Government, considering the following evaluation factors: 1. Technical Acceptability 2. Past Performance 3. Price 5.1 Technical Acceptability Technical acceptability is the most important factor. The Government will evaluate whether the quoted product meets all salient characteristics and minimum requirements of this solicitation. For any �equal� product, the vendor must provide sufficient technical documentation to demonstrate equivalency, including product literature, specifications, brochures, and point-by-point crosswalk to each salient characteristic. Failure to clearly demonstrate compliance with all minimum requirements may render the quotation unacceptable. 5.2 Past Performance The Government will evaluate the vendor�s record of recent and relevant past performance. The Government may consider information obtained from the vendor, CPARS, prior Government experience, and other available sources. 5.3 Pice Price will be evaluated for fairness and reasonableness. The Government may make an award to other than the lowest-priced quotation if a higher-rated quotation is determined to provide the best value. 6. Quotation Instructions Vendors shall submit a complete quotation package that includes the following: 6.1 Volume I � Technical Quote The technical quote shall include: Manufacturer name and model number. Description of the quoted system. Point-by-point response to each salient characteristic. Description of included software, accessories, automation, warranty, applicable service. Delivery lead time; Installation. 6.2 Volume II � Past Performance Provide up to three examples of recent and relevant contracts or purchase orders for customer name, dollar value, period of performance, point of contact with email and phone number. 6.3 Volume III � Price Quote The price quote shall include: unit price, extended price, total quoted price, any shipping charges, warranty information, any other separately priced items. The total quoted price shall include all costs necessary to provide a complete and fully functional system meeting the requirements of this solicitation. 6.4 SAM Registration In order to receive an award, offerors/contractors must maintain an active SAM registration for all awards throughout the entire contract/order lifecycle, from offer submission to final payment. Failure to maintain an active SAM registration can the award or result in non-payment. Lack of valid registration in SAM will make an offerors/contractor ineligible for award. 6.5 Small Business Subcontracting Plan In accordance with FAR 52.219-9, other-than-small-business (large business) offerors must submit a Small Business Subcontracting Plan with their quote. This requirement does not apply to small business concerns. If the offeror represents itself as a small business under the designated NAICS code for this procurement, no subcontracting plan is required." Other-than-small-business offerors who determine that zero subcontracting opportunities exist for this microscope procurement are still required to submit a formal Small Business Subcontracting Plan. The plan must state 0% goals and include a detailed, written justification outlining why subcontracting is not feasible (e.g., fully integrated in-house manufacturing). Failure to submit a plan with the required justification will render the quote non-responsive." 7. Submission Instructions Quotations shall be submitted electronically to: Tina Robinson@ robinsti@mail.nih.gov Quotations are due no later than: August 13, 2026, prior to 9:00 AM Eastern Daylight Time Late submissions may be rejected and not considered for award. 8. Clauses and Provisions The following FAR provisions and clauses apply to this acquisition, in addition to any others required by law or agency policy: 52.212-1 Instructions to Offerors�Commercial Products and Commercial Services 52.240-90 Security Prohibitions and Exclusions�Representations and Certifications 52.203-17 Contractor Employee Whistleblower Rights 52.203-19 Prohibition on